Terapia Celular

Nalio Ramos R, Missolo-Koussou Y, Gerber-Ferder Y, Bromley CP, Bugatti M, Núñez NG, Tosello Boari J, Richer W, Menger L, Denizeau J, Sedlik C, Caudana P, Kotsias F, Niborski LL, Viel S, Bohec M, Lameiras S, Baulande S, Lesage L, Nicolas A, Meseure D, Vincent-Salomon A, Reyal F, Dutertre CA, Ginhoux F, Vimeux L, Donnadieu E, Buttard B, Galon J, Zelenay S, Vermi W, Guermonprez P, Piaggio E, Helft J. Tissue-resident FOLR2+ macrophages associate with CD8+ T cell infiltration in human breast cancer. Cell. 2022 Mar 31;185(7):1189-1207.e25. doi: 10.1016/j.cell.2022.02.021. Epub 2022 Mar 23. PMID: 35325594.

Nader GPF, Agüera-Gonzalez S, Routet F, Gratia M, Maurin M, Cancila V, Cadart C, Palamidessi A, Ramos RN, San Roman M, Gentili M, Yamada A, Williart A, Lodillinsky C, Lagoutte E, Villard C, Viovy JL, Tripodo C, Galon J, Scita G, Manel N, Chavrier P, Piel M. Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion. Cell. 2021 Sep 30;184(20):5230-5246.e22. Epub 2021 Sep 21. PMID: 34551315.

Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P. Transcriptional and Functional Analysis of CD1c+ Human Dendritic Cells Identifies a CD163+ Subset Priming CD8+CD103+ T Cells. Immunity. 2020 Aug 18;53(2):335-352.e8. Epub 2020 Jun 30. PMID: 32610077; PMCID: PMC7445430.

Leruste A, *Ramos RN, *Tosello J, Tauziède-Espariat A, Brohard S, Han ZY, Beccaria K, Andrianteranagna M, Caudana P, Nikolic J, Chauvin C, Niborski LL, Manriquez V, Richer W, Masliah-Planchon J, et al. Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors. Cancer Cell. 2019 Dec 9;36(6):597-612.e8. Epub 2019 Nov 7. PMID: 31708437. (*igual contribuição)

Ramos RN, Rodriguez C, Hubert M, Ardin M, Treilleux I, Ries CH, Lavergne E, Chabaud S, Colombe A, Trédan O, Guedes HG, Laginha F, Richer W, Piaggio E, Barbuto JAM, Caux C, Ménétrier-Caux C, Bendriss-Vermare N. CD163+ tumor-associated macrophage accumulation in breast cancer patients reflects both local differentiation signals and systemic skewing of monocytes. Clin Transl Immunology. 2020 Feb 13;9(2):e1108. PMID: 32082570; PMCID: PMC7017151.

Guimarães JA, Duarte ME, Fernandes MB, Vianna VF, Rocha TH, Bonfim DC, Casado PL, do Val Guimarães IC, Velarde LG, Dutra HS, Giannoudis PV. The effect of autologous concentrated bone-marrow grafting on the healing of femoral shaft non-unions after locked intramedullary nailing. Injury. 2014 Nov;45 Suppl 5:S7-S13. doi: 10.1016/S0020-1383(14)70013-0. PMID: 25528626.

Vianna VF, Bonfim DC, Cavalcanti Ados S, Fernandes MC, Kahn SA, Casado PL, Lima IC, Murray SS, Murray EJ, Duarte ME. Late adherent human bone marrow stromal cells form bone and restore the hematopoietic microenvironment in vivo. Biomed Res Int. 2013;2013:790842. doi: 10.1155/2013/790842. Epub 2013 Apr 24. PMID: 23710460; PMCID: PMC3655461.

Guimarães JM, Guimarães IC, Duarte ME, Vieira T, Vianna VF, Fernandes MB, Vieira AR, Casado PL. Polymorphisms in BMP4 and FGFR1 genes are associated with fracture non-union. J Orthop Res. 2013 Dec;31(12):1971-9. doi: 10.1002/jor.22455. Epub 2013 Aug 12. PMID: 23939983.

Ortiz Rojas CA, Costa-Neto A, Pereira-Martins DA, Le DM, Sternadt D, Weinhäuser I, Huls G, Schuringa JJ, Magalhães Rego E. High ME1 Expression Is a Molecular Predictor of Post-Transplant Survival of Patients with Acute Myeloid Leukemia. Cancers (Basel). 2022 Dec 31;15(1):296. doi: 10.3390/cancers15010296. PMID: 36612292; PMCID: PMC9818450.

Costa Neto A, Santos F, Ribeiro I, Oliveira V, Dezan M, Kashima S, Covas D, Pereira A, Fonseca G, Moreira F, Krieger J, Gualandro S, Rocha V, Mendrone A Jr, Dinardo CL. FcγR2B B2.4 haplotype predicts increased risk of red blood cell alloimmunization in sickle cell disease patients. Transfusion. 2020 Jul;60(7):1573-1578. doi: 10.1111/trf.15832. Epub 2020 May 4. PMID: 32681817

da Silva WF, Neto AC, da Rosa LI, de Siqueira IA, Amarante GD, Velloso EDRP, Rego EM, Rocha V, Buccheri V. Outcomes and second neoplasms in hairy cell leukemia: A retrospective cohort. Leuk Res. 2019 Aug;83:106165. doi: 10.1016/j.leukres.2019.06.001. Epub 2019 Jun 4. PMID: 31200147.

Costa Neto, A, Moraes, BDGC, Rocha, IMG, Bezerra, FA, Medeiros, GOC, Alves, LBO, Rossetti, RAM, Fayh, APT, Mariano, LCB, & Rocha, V (2018). Association of Sarcopenia with Toxicities and Survival after Autologous Hematopoietic Stem Cell Transplantation for Adults with Lymphomas. Blood, 132(Supplement 1), 2158–2158.

Axfors C, Janiaud P, Schmitt AM, Van’t Hooft J, Smith ER, Haber NA, Abayomi A, Abduljalil M, Abdulrahman A, Acosta-Ampudia Y, Aguilar-Guisado M, Al-Beidh F, Alejandria MM, Alfonso RN, Ali M, AlQahtani M, AlZamrooni A, Anaya JM, Ang MAC, Aomar IF, Argumanis LE, Averyanov A, Baklaushev VP, Balionis O, Benfield T, Berry S, Birocco N, Bonifacio LB, Bowen AC, Bown A, Cabello-Gutierrez C, Camacho B, Camacho-Ortiz A, Campbell-Lee S, Cao DH, Cardesa A, Carnate JM, Castillo GJJ, Cavallo R, Chowdhury FR, Chowdhury FUH, Ciccone G, Cingolani A, Climacosa FMM, Compernolle V, Cortez CFN, Costa Neto A, et al. Association between convalescent plasma treatment and mortality in COVID-19: a collaborative systematic review and meta-analysis of randomized clinical trials. BMC Infect Dis. 2021 Nov 20;21(1):1170. PMID: 34800996; PMCID: PMC8605464.

ALLAHDADI, K. J.; Hannan, Johanna L.; Tostes, Rita C.; Webb, R. Clinton. Endothelin-1 Induces Contraction of Female Rat Internal Pudendal and Clitoral Arteries through ET Receptor and Rho-Kinase Activation. The Journal of Sexual Medicine , p.2096 – 2103, 2010.

Allahdadi KJ, Walker BR, Kanagy NL. Augmented endothelin vasoconstriction in intermittent hypoxia-induced hypertension. Hypertension. 2005 Apr;45(4):705-9. Epub 2005 Feb 28. PMID: 15738350.

da Silva KN, Gobatto ALN, Costa-Ferro ZSM, Cavalcante BRR, Caria ACI, de Aragão França LS, Nonaka CKV, de Macêdo Lima F, Lopes-Pacheco M, Rocco PRM, de Freitas Souza BS. Is there a place for mesenchymal stromal cell-based therapies in the therapeutic armamentarium against COVID-19? Stem Cell Res Ther. 2021 Jul 27;12(1):425.

da Silva KN, Pinheiro PCG, Gobatto ALN, Passos RDH, Paredes BD, França LSA, Nonaka CKV, Barreto-Duarte B, Araújo-Pereira M, Tibúrcio R, Cruz FF, Martins GLS, Andrade BB, de Castro-Faria-Neto HC, Rocco PRM, Souza BSF. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Front Med (Lausanne). 2021 Nov 17;8:767291. eCollection 2021.

Santos ES, de Aragão-França LS, Meira CS, Cerqueira JV, Vasconcelos JF, Nonaka CKV, Pontes-de-Carvalho LC, Soares MBP. Tolerogenic Dendritic Cells Reduce Cardiac Inflammation and Fibrosis in Chronic Chagas Disease. Front Immunol. 2020 Apr 7;11:488. eCollection 2020.

Duarte CA, Goulart LR, Filice LSC, Lima IL, Campos-Fernández E, Dantas NO, Silva ACA, Soares MBP, Santos RRD, Cardoso CMA, França LSA, Rocha VPC, Ribeiro ARLP, Perez G, Carvalho LN, Alonso-Goulart V. Characterization of Crystalline Phase of TiO2 Nanocrystals, Cytotoxicity and Cell Internalization Analysis on Human Adipose Tissue-Derived Mesenchymal Stem Cells. Materials (Basel). 2020 Sep 14;13(18):4071.

A clinical score to predict mortality in septic acute kidney injury patients requiring continuous renal replacement therapy: the HELENICC score

Inclusion and definition of acute renal dysfunction in critically ill patients in randomized controlled trials: a systematic review

Ultrasound-based clinical profiles for predicting the risk of intradialytic hypotension in critically ill patients on intermittent dialysis: a prospective observational study

da Silva KN, Pinheiro PCG, Gobatto ALN, Passos RDH, Paredes BD, França LSA, Nonaka CKV, Barreto-Duarte B, Araújo-Pereira M, Tibúrcio R, Cruz FF, Martins GLS, Andrade BB, de Castro-Faria-Neto HC, Rocco PRM, Souza BSF. Immunomodulatory and Anti-fibrotic Effects Following the Infusion of Umbilical Cord Mesenchymal Stromal Cells in a Critically Ill Patient With COVID-19 Presenting Lung Fibrosis: A Case Report. Front Med (Lausanne). 2021 Nov 17;8:767291.

Portella DCN, Rossi EA, Paredes BD, Bastos TM, Meira CS, Nonaka CVK, Silva DN, Improta-Caria A, Moreira DRM, Leite ACL, de Oliveira Filho GB, Filho JMB, Dos Santos RR, Soares MBP, Souza BSF. A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Stem Cells Int. 2021 Aug 11;2021:2642807.

Matsuda T, Takami T, Sasaki R, Nishimura T, Aibe Y, Paredes BD, Quintanilha LF, Matsumoto T, Ishikawa T, Yamamoto N, Tani K, Terai S, Taura Y, Sakaida I. A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow-derived cells. Hepatol Commun. 2017 Jul 17;1(7):691-703.

Souza BS, Sampaio GL, Pereira CS, Campos GS, Sardi SI, Freitas LA, Figueira CP, Paredes BD, Nonaka CK, Azevedo CM, Rocha VP, Bandeira AC, Mendez-Otero R, Dos Santos RR, Soares MB. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells.Sci Rep. 2016 Dec 23;6:39775.

Paredes BD, Faccioli LA, Quintanilha LF, Asensi KD, do Valle CZ, Canary PC, Takiya CM, de Carvalho AC, Goldenberg RC. Bone marrow progenitor cells do not contribute to liver fibrogenic cells. World J Hepatol. 2012 Oct 27;4(10):274-83.

Nonaka CKV, Franco MM, Gräf T, de Lorenzo Barcia CA, de Ávila Mendonça RN, de Sousa KAF, Neiva LMC, Fosenca V, Mendes AVA, de Aguiar RS, Giovanetti M, de Freitas Souza BS. Genomic Evidence of SARS-CoV-2 Reinfection Involving E484K Spike Mutation, Brazil. Emerg Infect Dis. 2021 May;27(5):1522-1524.Epub 2021 Feb 19. PMID: 33605869; PMCID: PMC8084516.

Improta Caria, A.C.; Nonaka, C.K.V.; Pereira, C.S.; Soares, M.B.P.; Macambira, S.G.; Souza, B.S.d.F. Exercise Training-Induced Changes in MicroRNAs: Beneficial Regulatory Effects in Hypertension, Type 2 Diabetes, and Obesity. Int. J. Mol. Sci. 2018, 19, 3608.

Nonaka, C.K.V.; Macêdo, C.T.; Cavalcante, B.R.R.; Alcântara, A.C.d.; Silva, D.N.; Bezerra, M.d.R.; Caria, A.C.I.; Tavora, F.R.F.; Neto, J.D.d.S.; Noya-Rabelo, M.M.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Circulating miRNAs as Potential Biomarkers Associated with Cardiac Remodeling and Fibrosis in Chagas Disease Cardiomyopathy. Int. J. Mol. Sci. 2019, 20, 4064.

Nonaka, C.K.V.; Sampaio, G.L.; de Aragão França, L.; Cavalcante, B.R.; Silva, K.N.; Khouri, R.; Torres, F.G.; Meira, C.S.; de Souza Santos, E.; Macedo, C.T.; Paredes, B.D.; Rocha, V.P.C.; Rogatto, S.R.; Ribeiro dos Santos, R.; Souza, B.S.d.F.; Soares, M.B.P. Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease. Int. J. Mol. Sci. 2021, 22, 3307.

Evangelista, A.F., Vannier-Santos, M.A., de Assis Silva, G.S. et al. Bone marrow-derived mesenchymal stem/stromal cells reverse the sensorial diabetic neuropathy via modulation of spinal neuroinflammatory cascades. J Neuroinflammation 15, 189 (2018).

Allahdadi KJ, de Santana TA, Santos GC, Azevedo CM, Mota RA, Nonaka CK, Silva DN, Valim CXR, Figueira CP, Dos Santos WLC, do Espirito Santo RF, Evangelista AF, Villarreal CF, Dos Santos RR, de Souza BSF, Soares MBP. IGF-1 overexpression improves mesenchymal stem cell survival and promotes neurological recovery after spinal cord injury. Stem Cell Res Ther. 2019 May 21;10(1):146. PMID: 31113444; PMCID: PMC6530133.

SOUZA, BRUNO SOLANO DE FREITAS; SILVA, DANIELA NASCIMENTO; CARVALHO, REJANE HUGHES; SAMPAIO, GABRIELA LOUISE DE ALMEIDA; PAREDES, BRUNO DIAZ; ARAGÃO FRANÇA, LUCIANA; AZEVEDO, CARINE MACHADO; VASCONCELOS, JULIANA FRAGA; MEIRA, CASSIO SANTANA; NETO, PAULO CHENAUD; MACAMBIRA, SIMONE GARCIA; DA SILVA, KÁTIA NUNES; ALLAHDADI, KYAN JAMES; TAVORA, FABIO; DE SOUZA NETO, JOÃO DAVID; DOS SANTOS, RICARDO RIBEIRO; SOARES, MILENA BOTELHO PEREIRA Association of Cardiac Galectin-3 Expression, Myocarditis, and Fibrosis in Chronic Chagas Disease Cardiomyopathy. AMERICAN JOURNAL OF PATHOLOGY. , v.187, p.1134 – 1146, 2017.